June 26, 2014
Prolonged expression of an anti-HIV-1 gp120 minibody to the female rhesus macaque lower genital tract by AAV gene transfer.
May 27-29, 2014
Dr. Marasco speaking at the MENA meeting in Doha, Qatar
May 1, 2014
Molecular Signatures of Hemagglutinin Stem-Directed Heterosubtypic Human Neutralizing Ab against Flu
April 28, 2014
Identification of human neutralizing antibodies against MERS-CoV and their role in virus adaptive evolution
- Molecular signatures occur in the VH domain of anti-influenza stem Abs.
- Rare VH-segment signatures occur in non-classical somatic hypermutation positions.
- Anti-influenza stem BnAbs can be generated with as few as one VH substitutions.
- Distinctive CDR-H2 substitutions facilitate HA binding of anchor residues.
Left - The location of F10 binding on the HA is shown with HA1 colored in salmon and HA2 colored in grey. Right panel – The location of contact CDR residues. In light green is the HA2 fusion peptide from Trp212-to-Val182.